Margarettsville, North Carolina, USA, is an unincorporated community in northern Northampton County. The community is part of the Roanoke Rapids, North Carolina Micropolitan Statistical Area. It is on North Carolina Highway 186, near the North Carolina-Virginia border. It is northeast of Turners Crossroads, has a Baptist Church, and a speedway, and is east of Seaboard. It has an unofficial population of 763.