Sardis is an unincorporated community in southeastern Lee Township, Monroe County, Ohio, United States. Although it is unincorporated, it has a post office with the ZIP code of 43946. It lies at the intersection of State Routes 7 and 255. An Ohio River town, it lies below Hannibal and above New Matamoras. Sardis shares a consolidated high school (River Pilots) with Antioch, Duffy, Fly, Hannibal, Laings, Powhatan Point, and Clarington.