Wadesville is an unincorporated community in northern Center Township, Posey County, Indiana, United States. It lies along State Road 66 northeast of the city of Mt. Vernon, the county seat of Posey County. Its elevation is 479 feet (146 m), and it is located at 38°6′9″N 87°47′10″W﻿ / ﻿38.1025°N 87.78611°W﻿ / 38.1025; -87.78611 (38.1025438, -87.7861367). Although Wadesville is unincorporated, it has a post office, with the ZIP code of 47638.