Gladstone is a city in Delta County in the U.S. state of Michigan. First settled in 1877, Gladstone's original name was Saunders Point. The population was 5,032 at the 2000 census. U.S. Routes 2 and 41 run concurrently through the city, connecting with Escanaba, nine miles to the south. US 41 runs north to Marquette and US 2 runs east to Manistique. M-35 runs northwest 52 miles to Gwinn and merges with US 2/US 41 south to Escanaba.