Villanova is a community in the United States Commonwealth of Pennsylvania. It straddles Lower Merion Township of Montgomery County and Radnor Township of Delaware County. It is located at the center of the Pennsylvania Main Line, a series of highly affluent Philadelphia suburban towns located along the original east-west railroad tracks of the Pennsylvania Railroad. It is served by the SEPTA R5 regional rail train and Route 100 high-speed line. The center of the village straddles Lancaster Pike where it intersects Spring Mill. This village center contains the area's post office for zip code 19085, an office building, the Wilmington Trust Company's Pennsylvania headquarters, and several smaller shops. The Royal Bank of Pennsylvania also maintains an office at this site.