Piseco is a small hamlet in the town of Arietta in Hamilton County, New York, United States. The name Piseco is that of a Native American known to an early surveyor. Located in the heart of the Adirondacks, the hamlet is home to Piseco Lake and Piseco Airport. The Northville-Placid Trail runs in close proximity to Piseco Lake and the airport. The village of Speculator lies 10 miles east of Piseco Lake.