Irene is an unincorporated community in Hill County, Texas, United States. It is located approximately twelve miles southeast of Hillsboro, near the intersection of FM 308 and FM 1946. Irene had an estimated population of 170 in 2000. Area students attend school in the nearby town of Bynum's supporting school district. Although it is unincorporated, it has a post office and its ZIP code is 76650.