Preston (also Pleasant Springs) is an unincorporated community in Kemper County, Mississippi, United States. It lies at the intersection of State Highways 21 and 397 northwest of the city of De Kalb, the county seat of Kemper County. Preston, MS is home to the "Crazy Dawg Lady," director of the Helter Skelter Animal Shelter. Its elevation is 541 feet (165 m). Although it is unincorporated, it has a post office, with the ZIP code of 39354.