Wyaconda is a city in Clark County, Missouri, United States. The population was 310 at the 2000 census. The city was organized in 1888 and is named after a Siouan name for God or the Great Spirit. The first land purchased from the Santa Fe and Land Co. was in 1888. Wyaconda is part of the Fort Madison–Keokuk, IA-MO Micropolitan Statistical Area.