Greensburg is a city in central Kiowa County, located in Southwest Kansas, in the Central United States. The population was 1,574 at the 2000 census. It is the county seat and most populous city of Kiowa County. Greensburg is also home to the world's largest hand-dug well. On May 4, 2007, Greensburg was devastated by an EF5 tornado that traveled rapidly through the area, leveling at least 95 percent of the city and killing eleven people.