Huntsville is a city centrally located in the northernmost part of the U.S. state of Alabama. It is located in Madison County and extends west into neighboring Limestone county. Huntsville is the county seat of Madison County, and the fourth-largest city in Alabama. The 2000 census estimated Huntsville's population at 158,216, while in 2008, the estimated population grew to 176,645. The Huntsville Metropolitan Area's population was estimated at 395,645. Huntsville is the largest city in the four-county Huntsville-Decatur Combined Statistical Area, which in 2008 had a total population of 545,770. John Hunt first settled in the location in 1805. It was named Twickenham after Alexander Pope's English home at the request of LeRoy Pope. However, the town was renamed "Huntsville" on November 25, 1811 after its first settler. It has grown across nearby hills and along the Tennessee River, adding textile mills, then munitions factories, to become a major city, including NASA's Marshall Space Flight Center and the United States Army Aviation and Missile Command nearby at the Redstone Arsenal. The National Trust for Historic Preservation named Huntsville to its "America's Dozen Distinctive Destinations for 2010" list.