Jonesboro is a city in and one of the three county seats of Craighead County, Arkansas, United States. According to 2005 Census Bureau estimates, the population of the city was 59,358. A college town, Jonesboro is the largest city in northeastern Arkansas and the fifth most populous city in the state. It is the principal city of and is included in the Jonesboro, Arkansas Metropolitan Statistical Area. The Jonesboro metropolitan area had an estimated population of 115,830 and 153,427 in the Jonesboro-Paragould Combined Statistical Area in 2006. Jonesboro is the home to Arkansas State University and is a regional center for manufacturing, agriculture, medicine, education, and trade.