Scott City is a city in Cape Girardeau and Scott counties in the U.S. state of Missouri. The population was 4,591 at the 2000 census. The Scott County portion of Scott City (the majority) is part of the Sikeston Micropolitan Statistical Area, while the Cape Girardeau County portion is part of the Cape Girardeau–Jackson, MO-IL Metropolitan Statistical Area. In December 1848, a cholera epidemic was brought to New Orleans by emigrant ships. Within a few weeks it was carried to all the principal cities on the Ohio and Mississippi Rivers. Six of the victims were Irish monks headed to a monastery near Dubuque, Iowa. These monks were buried a few hundred yards northwest of the Thebes-Scott City railroad bridge.