Wayne is a village in DuPage and Kane County, Illinois. The eastern portion, in Dupage County, is in Wayne Township while the western portion, in Kane County, is in St. Charles Township. The population was 2,137 at the 2000 census. In the late 19th and early 20th century, Wayne was a prominent center of horse breeding and farming research. The community was known for breeding French Percheron horses, a draft horse similar to a Clydesdale.