Picher was a city in Ottawa County, Oklahoma, United States. It was formerly a center of lead and zinc mining. The population was 1,640 at the 2000 census. Discoveries of ground contamination and the possibility of a cave-in of mines under the city have prompted all of its population to evacuate, and the nearby town of Cardin is following suit. The town is within the boundaries of the Tar Creek Superfund site.