Caleb Blood Smith (April 16, 1808 – January 7, 1864) was a United States representative from Indiana, the 6th U.S. secretary of the interior and a district judge of the United States District Court for the District of Indiana.

Caleb Blood Smith
Born 1808 in Boston, MA
Died 1864 in Indianapolis, IN
FJC ID: 2212
- Gender
- Male
- Race
- White
Prior employment
- Secretary of the Interior1861–1863
- Private practice, Cincinnati, Ohio1851–1859
- board of commissioners to adjust claims against MexicoMember · 1849–1851
- U.S. representative from Indiana1843–1849
- Private practice, Connersville, Indiana1828–1843
- IndianaState representative · 1832–1837, 1840–1841
- IndianaCommissioner to collect assets and adjust debts · 1837
- Indiana SentinelEditor · 1832
Appointments
- U.S. District Court for the District of Indiana1862–1864 · Appointed by Abraham Lincoln (Republican)Term ended: Death

Education
- Miami University, Ohio
- Cincinnati College (now University of Cincinnati)
- Read law1828