physical impairment

any physiological disorder, or condition, cosmetic disfigurement, or anatomical loss affecting one or more of the following body systems: neurological, musculoskeletal, special sense organs, respiratory (including speech organs), cardiovascular, reproductive, digestive, genito-urinary, hemic and lymphatic, skin, and endocrine.

Defined by the Supreme Court in Karen Sutton Kimberly Hintons v. United Air Lines Inc, 527 U.S. 471.