C.R.S. § 42-20-501

(1) No transportation of nuclear materials shall take place in, to, from, or through this state until the department of transportation issues a permit, in accordance with the provisions of this section, which is not inconsistent with federal law, authorizing the applicant to operate or move upon public roads of this state a motor vehicle or combination of motor vehicles which carry nuclear materials. (2) Each carrier desiring to transport nuclear materials shall submit a permit application, in the form designated by the department of transportation, to the department before beginning such transportation.