No permit may be issued which authorizes any discharge or injection of fluids through a well into any waters of the State:
1. Of any radiological, chemical or biological warfare agent or high-level radioactive waste;
2. Which would substantially impair anchorage and navigation in any waters of the State;
3. Which would result in the degradation of existing or potential underground sources of drinking water;
4. Which is inconsistent with an applicable areawide plan for management of the treatment of waste; or
5. Which the Director determines is inconsistent with the regulations and guidelines adopted by the Commission pursuant to NRS 445A.300 to 445A.730, inclusive, including those relating to standards of water quality and injections of fluids through a well.