Huntington is a city in Cabell and Wayne counties in the U.S. state of West Virginia, along the Ohio River. Most of the city is in Cabell County, for which it is the county seat. A small portion of the city, mainly the neighborhood of Westmoreland, is in Wayne County. Its population was estimated at 49,185 in 2008. Huntington is a part of the Huntington-Ashland, WV-KY-OH, Metropolitan Statistical Area (MSA). As of current 2005 data, the MSA's population was 286,012. Huntington is the largest city within the MSA and the second largest city in West Virginia, behind Charleston. The city is also the home of Marshall University.